Recombinant human TSN protein
Translin, also known TSN, is a DNA and RNA binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin forms a ring-shaped structure, which is responsible for DNA binding, and also contains a leucine zipper motif, which is thought to enable translin to form dimers. Translin exports specific mRNAs out of the nucleus, supported by its localization in both the nuclei and cytoplasm of neurons, and regulates their translation. Recombinant human Translin protein, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Translin, BCLF-1, RCHF1, REHF-1, TBRBP, TRSLN
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
26.1 kDa (228aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Gu W., et al. (1998) Mol Reprod Dev. 49:219-228.; ; Aoki K., et al. (1999) FEBS Lett. 443:363-366.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol 100 mM NaCl
Scientific Category
Transportation
NCBI Accession Number
NP_004613
Uniprot Accession Number
Q15631
Species
Human
AA Sequence
Frequently Asked Questions
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