Recombinant human IMPA1/IMP1 protein

IMPA1 (inositol monophosphatase1) is responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. It plays a key role in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis of inositol monophosphates. This protein has been identified as the pharmacological target for lithium action in the brain. Recombinant human IMPA1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Inositol monophosphatase 1, IMPA, IMP, IMPase 1, Inositol monophosphatase 1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

32.3 kDa (297aa) confirmed by MALDI-TOF

Additionnal Information

IMPA1, IMP1, ATGP0737-10 µg, ATGP0737-20 µg, ATGP0737-50 µg, ATGP0737-100 µg, ATGP0737-250 µg, ATGP0737-500 µg, ATGP0737-1 mg, ATGP0737-10, ATGP0737-20, ATGP0737-50, ATGP0737-100, ATGP0737-250, ATGP0737-500, ATGP0737-1

References & Citations

Schapiro MB., et al. (2002) Neurobiol Aging. 23 (3) :389-96.; ; Atack JR., et al. (1992) Proc Natl Acad Sci u S A. 89 (21) :10031-5.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Metabolism

NCBI Accession Number

NP_005527

Uniprot Accession Number

P29218

Species

Human

AA Sequence

MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPETVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED