Recombinant human LSM1 protein
U6 snRNA-associated Sm-like protein LSm1, also known as LSM1 plays a role in replication-dependent histone mRNA degradation and binds specifically to the 3'-terminal u-tract of u6 snRNA. LSM1 protein facilitates RNA protein interactions and structural changes that are required during ribosomal subunit assembly. LSM1 is naturally overexpressed in pancreatic cancer as well as in certain breast cancer cell lines. Recombinant human LSM1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
U6 snRNA-associated Sm-like protein LSm1, CASM, Small nuclear ribonuclear CaSm, u6 snRNA-associated Sm-like protein LSm1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
17.3 kDa (153aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Noueiry A O., et al. (2003) Mol Cell Biol. 23:4094-4106.; ; Kufel J., et al. (2003) J Biol Chem. 278:2147-2156.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 1mM DTT, 10% glycerol, 0.1M NaCl
Scientific Category
Cancer
NCBI Accession Number
NP_055277
Uniprot Accession Number
O15116
Species
Human
AA Sequence
MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI HVGKKYGDIP RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR VEQQTKLEAE KLKVQALKDR GLSIPRADTL DEY
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