Recombinant human PD-ECGF/TYMP protein
Thymidine phosphorylase precursor, also known TYMP, is a platelet-derived endothelial cell growth factor that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate. It is an angiogenic inducer that potently stimulates the growth of endothelial cells and induces chemotaxis. Increased expression of TYMP is seen in a wide variety of different solid tumors and inflammatory diseases and is often associated with poor prognosis. Recombinant human TYMP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Thymidine phosphorylase, ECGF1, hPD-ECGF, MNGIE, PDECGF, TP, Gliostatin, Platelet-derived endothelial cell growth factor, TdRPase
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
51.3 kDa (493aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Heldin C H., et al. (1991) J Cell Biochem. 47:208-210.; ; Furukawa T., et al. (1992) Nature. 356:668.;
Other References
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Scientific Category
Growth factors
NCBI Accession Number
NP_001107228
Uniprot Accession Number
P19971
Species
Human
AA Sequence
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