Recombinant human Secretagogin protein
SCGN, also known as secretagogin, is a cytoplasmic protein that contains six EF-hand domains and is related to the calicium-binding proteins Calretinin and Calbindin D28K. This protein is thought to be involved in cell proliferation and KCl (potassium chloride) -mediated calcium flux events. Through its interaction with KCl and its subsequent ability to modulate calcium storage pools within the cell, SCGN may function to negatively control growth and differentiation rates and, thus, indirectly inhibit cell replication. Recombinant SCGN protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Secretagogin, CALBL, DJ501N12.8, SECRET, SEGN, setagin, Secretagogin
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
34.2 kDa (296aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Wagner L., et al. (2000) J Biol Chem. 275 (32) :24740-51. ; ; Gartner W., et al. (2001) Cereb Cortex. 11 (12) :1161-9.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.
Scientific Category
Neuroscience
NCBI Accession Number
NP_008929
Uniprot Accession Number
O76038
Species
Human
AA Sequence
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