Recombinant human Fibrillarin/FBL protein
FBL is a key small nucleolar protein in eukaryotes, which has an important role in pre-rRNA processing during ribosomal biogenesis. It is associated with the u3, u8, and u13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. This protein is a component of several ribonucleoproteins including a nucleolar small nuclear ribonucleoprotein (SnRNP) and one of the two classes of small nucleolar ribonucleoproteins (snoRNPs) . Recombinant human FBL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
28.9 kDa (262aa), confirmed by MALDI-TOF
Additionnal Information
References & Citations
Amin MA, et al. (2007) Biochem Biophys Res Commun. 360 (2) :320-6; ; Jansen RP, et al. (1991) J Cell Biol 113 (4) : 715-29;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol, 1mM EDTA
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_001427
Uniprot Accession Number
P22087
Species
Human
AA Sequence
Frequently Asked Questions
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