Recombinant human SEPT2/SEPTIN2 protein
Septin2 (SEPT2) is a GTPase that is required for cytokinesis and associated with exocytosis. This protein can hetero-oligomerize with Septin6, 7 and also plays a role in the organization of new growth in organisms. It is associated with a Tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Recombinant human Septin2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Septin 2, hNedd5, KIAA0158, DIFF6, Pnutl3
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
43.6 kDa (381aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Low C, et al.. (2006) J Biol Chem. 281 (41) :30697-706.; ; Kremer BE, et al. (2007) Cell. 130 (5) :837-50.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 0.1M NaCl,1mM DTT
Scientific Category
Cell Cycle
NCBI Accession Number
AAH14455
Uniprot Accession Number
Q15019
Species
Human
AA Sequence
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