Recombinant human NAPA protein
NAPA is one of the SNAP (Soluble NSF Attachment Protein) family. SNAPs, acting in concert with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF), are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. This protein mediates the binding of NSF and thus the formation of a 20S fusion particle. It is expressed in all mammalian tissues. Recombinant human NAPA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
N-ethylmaleimide-sensitive factor attachment protein alpha, NSF attachment protein alpha, SNAPA, SNAP-alpha
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
35.3 kDa (315aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Thummel CS., et al. (2010) Dev Dyn. 239 (3) :954-64; ; Lee JS., et al (2002) J Basic Microbiol. 42 (4) :238-45.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_003818
Uniprot Accession Number
P54920
Species
Human
AA Sequence
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