Recombinant human PRL-2/PTP4A2 protein

Protein tyrosine phosphatase type IVA 2 isoform 1, also known as PTP4A2, belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTP4A2 is localized to the early endosome that play regulatory roles in a variety of cellular processes. This protein was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Recombinant human PTP4A2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Protein tyrosine phosphatase type IVA 2 isoform 1, HH13, HH7-2, Hu-PP-1, OV-1, PRL-2, PRL2, ptp-IV1a, ptp-IV1b, PTP4A, PTPCAAX2, EC 3.1.3.48, HH13, HH7 2, HuPP 1, HuPP1, OV 1, OV1, PRL 2, PRL2, Protein tyrosine phosphatase 4a2, Protein tyrosine phosphatase of regenerating liver 2, Protein tyrosine phosphatase type IVA member 2 isoform 1, PTP (CAAXII), ptp IV1a, ptp IV1b, PTP4A, PTPCAAX2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

23.2 kDa (203aa) confirmed by MALDI-TOF

Additionnal Information

PRL2, PTP4A2, Protein tyrosine phosphatase type IVA 2 isoform 1, HH13, HH7-2, Hu-PP-1, OV-1, PRL-2, PRL2, ptp-IV1a, ptp-IV1b, PTP4A, PTPCAAX2, EC 3.1.3.48, HH13, HH7 2, HuPP 1, HuPP1, OV 1, OV1, PRL 2, PRL2, Protein tyrosine phosphatase 4a2, Protein tyrosine phosphatase of regenerating liver 2, Protein tyrosine phosphatase type IVA member 2 isoform 1, PTP (CAAXII), ptp IV1a, ptp IV1b, PTP4A, PTPCAAX2, ATGP0705-10 µg, ATGP0705-20 µg, ATGP0705-50 µg, ATGP0705-100 µg, ATGP0705-250 µg, ATGP0705-500 µg, ATGP0705-1 mg, ATGP0705-10, ATGP0705-20, ATGP0705-50, ATGP0705-100, ATGP0705-250, ATGP0705-500, ATGP0705-1

References & Citations

Si X., et al. (2001) J Biol chem. 246 (35) :32875-82.; ; Werner SR., et al. (2003) Cancer Lett. 202 (2) :201-11.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_536316

Uniprot Accession Number

Q12974

Species

Human

AA Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNRP APVEISYENM RFLITHNPTN ATLNKFTEEL KKYGVTTLVR VCDATYDKAP VEKEGIHVLD WPFDDGAPPP NQIVDDWLNL LKTKFREEPG CCVAVHCVAG LGRAPVLVAL ALIECGMKYE DAVQFIRQKR RGAFNSKQLL YLEKYRPKMR LRFRDTNGHC CVQ