Recombinant human GMPR2 protein
Guanosine monophosphate reductase 2, also known as GMPR2, is the only known metabolic step by which guanine nucleotides can be converted to the pivotal precursor of both adenine and guanine nucleotides. GMPR2 catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP, and plays a critical role in re-utilization of free intracellular bases and purine nucleosides. Recombinant human GMPR2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Guanosine monophosphate reductase 2, GMP reductase 2, Guanosine 5'-monophosphate oxidoreductase 2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
40 kDa (368aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Li J., et al. (2006) J Mol Biol. 355 (5) :980-8.; ; Denq Y., et al. (2002) Int J Biochem Cell Biol. 34 (9) :1035-50.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_001002002
Uniprot Accession Number
Q9P2T1
Species
Human
AA Sequence
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