Recombinant human RCL protein
Deoxyribonucleoside 5'-monophosphate N-glycosidase isoform 1, also known as RCL, belonged to the N-deoxyribosyltransferase family. This protein catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. RCL was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. Recombinant human RCL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Deoxyribonucleoside 5'-monophosphate N-glycosidase isoform 1, c-Myc-responsive protein Rcl, C6orf108
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
21.2 kDa (194aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Ghiorghi Y K., et al. (2007) J Biol Chem. 282 (11) :8150-6.; ; Munqall A J., et al. (2003) Nature. 425 (6960) :805-11.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_006434
Uniprot Accession Number
O43598
Species
Human
AA Sequence
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