Recombinant human Sorting Nexin 1/SNX1 protein

SNX1 (Sorting nexin 1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking. SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor. This protein is all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and Insulin receptor tyrosine kinases. Recombinant human SNX1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Sorting nexin-1, HsT17379, SNX1A, Vps5

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

48.0 kDa (415aa) confirmed by MALDI-TOF

Additionnal Information

SNX1, Sorting nexin-1, HsT17379, SNX1A, Vps5, Sorting nexin-1, ATGP0697-10 µg, ATGP0697-20 µg, ATGP0697-50 µg, ATGP0697-100 µg, ATGP0697-250 µg, ATGP0697-500 µg, ATGP0697-1 mg, ATGP0697-10, ATGP0697-20, ATGP0697-50, ATGP0697-100, ATGP0697-250, ATGP0697-500, ATGP0697-1

References & Citations

Kurten RC, et al.. (1996) Science 272 (5264) : 1008-10; ; Parks WT, et al. (2001) J. Biol. Chem. 276 (22) : 19332-9;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.1M NaCl,1mM DTT

Scientific Category

Signal Transduction

NCBI Accession Number

NP_003090.2

Uniprot Accession Number

Q13596

Species

Human

AA Sequence

TV GITDPEKIGD GMNAYVAYKV TTQTSLPLFR SKQFAVKRRF SDFLGLYEKL SEKHSQNGFI VPPPPEKSLI GMTKVKVGKE DSSSAEFLEK RRAALERYLQ RIVNHPTMLQ DPDVREFLEK EELPRAVGTQ TLSGAGLLKM FNKATDAVSK MTIKMNESDI WFEEKLQEVE CEEQRLRKLH AVVETLVNHR KELALNTAQF AKSLAMLGSS EDNTALSRAL SQLAEVEEKI EQLHQEQANN DFFLLAELLS DYIRLLAIVR AAFDQRMKTW QRWQDAQATL QKKREAEARL LWANKPDKLQ QAKDEILEWE SRVTQYERDF ERISTVVRKE VIRFEKEKSK DFKNHVIKYL ETLLYSQQQL AKYWEAFLPE AKAIS