Recombinant human Calbindin 2/CALB2 protein
CALB2 is an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Recombinant human CALB2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CR, Calretinin, CALB2, CAL2, CAB29, 29 kDa calbindin
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
33.7 kDa (291aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Rogers J.H., et al. (1987) J. Cell Biol. 105 (3) :1343-53; ; Dreher B., et al. (1996) J. Comp. Neurol. 376 (2) :223-40;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
AAH15484
Uniprot Accession Number
P22676
Species
Human
AA Sequence
Frequently Asked Questions
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