Recombinant human Calbindin 2/CALB2 protein

CALB2 is an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Recombinant human CALB2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

CR, Calretinin, CALB2, CAL2, CAB29, 29 kDa calbindin

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

33.7 kDa (291aa) confirmed by MALDI-TOF

Additionnal Information

Calretinin, CALB2, Calretinin, CALB2, CAL2, CR, 29 kDa calbindin, Calretinin, ATGP0694-10 µg, ATGP0694-20 µg, ATGP0694-50 µg, ATGP0694-100 µg, ATGP0694-250 µg, ATGP0694-500 µg, ATGP0694-1 mg, ATGP0694-10, ATGP0694-20, ATGP0694-50, ATGP0694-100, ATGP0694-250, ATGP0694-500, ATGP0694-1

References & Citations

Rogers J.H., et al. (1987) J. Cell Biol. 105 (3) :1343-53; ; Dreher B., et al. (1996) J. Comp. Neurol. 376 (2) :223-40;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Neuroscience

NCBI Accession Number

AAH15484

Uniprot Accession Number

P22676

Species

Human

AA Sequence

MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSST EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M