Recombinant human Annexin A8/ANXA8 protein

ANXA8, also known as Annexin A8, a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Where co-expressed in the same tissues, ANXA8 is often expressed at a 100-fold lower level than Annexin A5. However, ANXA8 is preferentially expressed in acute promyelocytic leukemia (APL) cells which may relate to its role in hematopoietic cell differentiation. Recombinant human ANXA8 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Annexin VIII, Annexin-8, Vascular anticoagulant-beta, VAC-beta, ANX8

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

39.0 kDa (347aa) confirmed by MALDI-TOF

Additionnal Information

Annexin A8, Annexin A8, ANX8, Annexin-8, Annexin VII, Vascular anticoagulant-beta, VAC-beta, Annexin A8, ATGP0682-10 µg, ATGP0682-20 µg, ATGP0682-50 µg, ATGP0682-100 µg, ATGP0682-250 µg, ATGP0682-500 µg, ATGP0682-1 mg, ATGP0682-10, ATGP0682-20, ATGP0682-50, ATGP0682-100, ATGP0682-250, ATGP0682-500, ATGP0682-1

References & Citations

Movitz C., et al. (2010) J Biol Chem. 285 (19) :14338-45.; ; Torosyan Y., et al. (2010) Oncogene. 29 (17) :2457-66.;

Other References

Sakamoto N et al., Anti-annexin A4 antibody as a biomarker for desquamative interstitial pneumonia. (J Autoimmun. 2025) {https://pubmed.ncbi.nlm.nih.gov/40156961/}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 1mM EDTA, 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_001035173

Uniprot Accession Number

P13928

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG KTLSSMIMED TSGDYKNALL SLVGSDP