Recombinant human ACADVL protein
ACADVL, also known as VLCAD, LCACD or ACAD6, is an inner mitochondrial membrane protein that belongs to the family of acyl-CoA dehydrogenases. This protein is involved in lipid metabolism and has catalytic activity toward esters of long chain and very long chain fatty acids such as palmitoyl-CoA and stearoyl-CoA, and functions in the first step of the fatty acid beta-oxidation pathway. A deficiency in this gene product reduces myocardial fatty acid beta-oxidation and is associated with cardiomyopathy. Recombinant human ACADVL protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Very long-chain specific acyl-CoA dehydrogenase mitochondrial, ACAD6, LCACD, VLCAD, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
68.5 kDa (636aa)
Additionnal Information
References & Citations
Smelt AH., et al. (1998) Ann Neurol. 43 (4) :540-4. ; ; Souri M., et al. (1996) Am J Hum Genet. 58 (1) :97-106. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT, 1mM EDTA, 0.1M NaCl.
Scientific Category
Enzymes & Proteases
NCBI Accession Number
NP_000009
Uniprot Accession Number
P49748
Species
Human
AA Sequence
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