Recombinant human BIN1 protein
BIN1, also known as SH3P9, is a nucleocytoplasmic adaptor protein, one of which was initially identified as MYC-interacting protein with features of a tumor suppressor. This protein interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Recombinant human BIN1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Myc box-dependent-interacting protein 1, AMPH2, AMPHL, MGC10367, SH3P9, Amphiphysin II, Myc box-dependent-interacting protein 1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
50.4 kDa (459aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sakamuro D., et al. (1996) Nat Genet. 14 (1) :69-77. ; ; Nanda SK., et al. (2006) Gastroenterology. 130 (3) :794-809.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Scientific Category
Cancer
NCBI Accession Number
AAH04101.1
Uniprot Accession Number
Q9BTH3
Species
Human
AA Sequence
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