Recombinant human Tau 352 (0N3R) /MAPT protein
MAPT, also known as TAu, is a neuronal microtubule associated protein found predominantly on axons. The function of this protein is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. MAPT, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Recombinant human MAPT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by BCA assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
38.9 kDa (372aa) confirmed by MALDI-TOF (Real Molecular weight on SDS-PAGE will be shift up)
Additionnal Information
References & Citations
Jack CR Jr., et al. (2010) Lancet Neurol. 9 (1) :119-28.; ; Buescher JL., et al. (2010) J Biol Chem. 285 (11) :7957-63.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M Nacl, 1mM DTT, 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_058525
Uniprot Accession Number
P10636
Species
Human
AA Sequence
Frequently Asked Questions
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