Recombinant human Snurportin 1/SNUPN protein
SNUPN, also known as KPNBL or RNUT1, is a nuclear import adaptor protein belonging to the Snurportin family. Localizing to the cytoplasm and nucleus, Snurportin-1 contains an N-terminal IBB domain and a trimethylguanosine (m3G) -cap binding domain. It specifically binds the terminal 2, 2, 7-m3G-cap at the 5' end of u snRNPs and functions to transport u snRNPs into the nucleus via an association with Importin beta. Recombinant human Snurportin-1 protien, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
RNA U transporter 1, SNURPORTIN-1, RNUT1, SPN1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
43.3 (380aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Huber J., et al. (1998) EMBO J. 17 (14) :4114-26.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.1M NaCl
Scientific Category
Adhesion & Movement
NCBI Accession Number
NP_001036053
Uniprot Accession Number
O95149
Species
Human
AA Sequence
Frequently Asked Questions
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