Recombinant human WDR5 protein
WDR5, also designated BMP-2-induced gene 3 kb or BIG-3, belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. This protein is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. WDR5 may play a role in its function of accelerating osteoblast differentiation. Recombinant human WDR5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
WD repeat-containing protein 5, BIG-3, SWD3, WD repeat-containing protein 5, BIG 3, WDR 5, WDR-5
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
38.8 kDa (354aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Yokoyama., et al. (2004) Mol Cell Biol. 24 (13) :5639-49. ; ; Gori F., et al. (2001) J Biol Chem. 276 (49) :46515-22. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_438172.1
Uniprot Accession Number
P61964
Species
Human
AA Sequence
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