Recombinant human TIP30/HTATIP2 protein

HTATIP2, also known as TIP30, is a member of the short-chain dehydrogenases/reductases (SDR) family. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II) . Defects in This protein are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for HTATIP2 in antitumor therapy. Recombinant human HTATIP2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Oxidoreductase HTATP2, CC3, TIP30, SDR44u1, Oxidoreductase HTATP2, HTATIP 2, HTATIP-2, CC-3, TIP 30, TIP-30

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

29.3 kDa (262aa) confirmed by MALDI-TOF

Additionnal Information

TIP-30, TIP30, TIP 30, SDR44u1, Oxidoreductase HTATP2, HTATIP-2, HTATIP2, HTATIP 2, CC-3, CC3, CC 3, ATGP0631-10 µg, ATGP0631-20 µg, ATGP0631-50 µg, ATGP0631-100 µg, ATGP0631-250 µg, ATGP0631-500 µg, ATGP0631-1 mg, ATGP0631-010, ATGP0631-020, ATGP0631-050, ATGP0631-100, ATGP0631-250, ATGP0631-500, ATGP0631-01M

References & Citations

Shtivelman E., et al. (1997) Oncogene. 14 (18) :2167-73. ; ; Xiao H., et al. (1998) Proc Natl Acad Sci u S A. 95 (5) :2146-2151.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT

Scientific Category

Cancer

NCBI Accession Number

AAH15358

Uniprot Accession Number

Q9BUP3

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP