Recombinant human COMMD1 protein
COMMD1, also known as copper metabolism MuRR1 domain-containing protein 1, is a 190 amino acid protein responsible for inhibition of TNF-induced NFkB p50 and has a suggested role in facilitation of biliary copper excretion within hepatocytes. High expression is found in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. This protein interacts directly with COMMD6 and ATP7B, and indirectly with IkB-beta and COMMD7. Recombinant human COMMD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
COMM domain-containing protein 1, C2orf5, MuRR1, COMM domain-containing protein 1, COMMD-1, COMMD 1, COMM, MuRR 1, MuRR-1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.3 kDa (210aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Van De Sluis B, et al. (2002) Hum Mol Genet. 11 (2) :165-73.; ; Muller T, et al. (2003) J Hepatol. 38 (2) :164-8.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol 0.1M NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_689729
Uniprot Accession Number
Q8N668
Species
Human
AA Sequence
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