Recombinant human COMMD1 protein

COMMD1, also known as copper metabolism MuRR1 domain-containing protein 1, is a 190 amino acid protein responsible for inhibition of TNF-induced NFkB p50 and has a suggested role in facilitation of biliary copper excretion within hepatocytes. High expression is found in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. This protein interacts directly with COMMD6 and ATP7B, and indirectly with IkB-beta and COMMD7. Recombinant human COMMD1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

COMM domain-containing protein 1, C2orf5, MuRR1, COMM domain-containing protein 1, COMMD-1, COMMD 1, COMM, MuRR 1, MuRR-1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

23.3 kDa (210aa) confirmed by MALDI-TOF

Additionnal Information

COMMD1, COMM domain-containing protein 1, C2orf5, MuRR1, COMM domain-containing protein 1, COMMD-1, COMMD 1, COMM, MuRR 1, MuRR-1, ATGP0630-10 µg, ATGP0630-20 µg, ATGP0630-50 µg, ATGP0630-100 µg, ATGP0630-250 µg, ATGP0630-500 µg, ATGP0630-1 mg, ATGP0630-10, ATGP0630-20, ATGP0630-50, ATGP0630-100, ATGP0630-250, ATGP0630-500, ATGP0630-1

References & Citations

Van De Sluis B, et al. (2002) Hum Mol Genet. 11 (2) :165-73.; ; Muller T, et al. (2003) J Hepatol. 38 (2) :164-8.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol 0.1M NaCl

Scientific Category

Signal Transduction

NCBI Accession Number

NP_689729

Uniprot Accession Number

Q8N668

Species

Human

AA Sequence

MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN