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Recombinant human MTPN protein

MTPN (myotrophin), an ankyrin repeat protein, is stimulates protein synthesis and cardiomyocyte growth to initiate cardiac hypertrophy by activating the NF-kappaB signaling cascade. This protein plays a potential role in cerebellar morphogenesis and may function in differentiation of cerebellar neurons, particularly of granule cells. Elevated levels of MTPN are expressed in human dilated cardiomyopathic and ischemic hearts. Recombinant human MTPN, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

Myotrophin, Protein V-1, GCDP, Myotrophin, Protein V 1, Protein V1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

15 kDa (138aa) confirmed by MALDI-TOF

Additionnal Information

MTPN, Myotrophin, Protein V-1, GCDP, Myotrophin, Protein V 1, Protein V1, ATGP0621-10 µg, ATGP0621-20 µg, ATGP0621-50 µg, ATGP0621-100 µg, ATGP0621-250 µg, ATGP0621-500 µg, ATGP0621-1 mg, ATGP0621-10, ATGP0621-20, ATGP0621-50, ATGP0621-100, ATGP0621-250, ATGP0621-500, ATGP0621-1

References & Citations

Sen S., et al. (2008) J Biol Chem. 283 (41) :27947-56.; ; Sivasubramanian N., et al (2002) J Biol Chem. 277 (26) :23888-97.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Neuroscience

NCBI Accession Number

NP_665807

Uniprot Accession Number

P58546

Species

Human

AA Sequence

MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPDGLTAFEATDN QAIKALLQ

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