Recombinant human DCXR protein

Dicarbonyl/L-xylulose reductase, also known as DCXR, is an enzyme responsible for the metabolism of xylulose, converting it into xylitol. DCXR was expressed at low levels and was localized predominantly in the cytoplasmic membrane. In contrast, in virtually all grades of early-stage prostate cancer and in all chemohormonally treated cases, DCXR was strikingly overexpressed and was localized predominantly in the cytoplasm and nucleus. Recombinant human DCXR, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Carbonyl reductase II, DCR, Dicarbonyl/L-xylulose reductase, HCR 2, HCR II, KIDCR, Kidney dicarbonyl reductase, L-xylulose reductase, P34H, Sperm surface protein P34H, XR

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

28 kDa (264aa) confirmed by MALDI-TOF

Additionnal Information

Carbonyl reductase II, DCR, DCXR, Dicarbonyl/L-xylulose reductase, HCR 2, HCR II, HCR2, HCR-2, HCRII, HCR-II, KIDCR, Kidney dicarbonyl reductase, L xylulose reductase, L-xylulose reductase, P34H, Sperm surface protein P34H, XR, ATGP0618-10 µg, ATGP0618-20 µg, ATGP0618-50 µg, ATGP0618-100 µg, ATGP0618-250 µg, ATGP0618-500 µg, ATGP0618-1 mg, ATGP0618-010, ATGP0618-020, ATGP0618-050, ATGP0618-100, ATGP0618-250, ATGP0618-500, ATGP0618-01M

References & Citations

Cho Veqa JH., et al. (2007) Cancer Epidemiol Biomakers Prev. 16 (12) :2615-22.; ; Nakaqawa J., et al. (2002) J Biol Chem. 277 (20) :17883-91.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 50 mM NaCl

Scientific Category

Metabolism

NCBI Accession Number

NP_057370

Uniprot Accession Number

Q7Z4W1

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC