Recombinant human ICAT/CTNNBIP1 protein
CTNNBIP1 binds CTNNB1 and prevents interaction between CTNNB1 and TCF (T-cell transcription factor) family members. This protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. Recombinant human CTNNBIP1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography
Product Specifications
Product Name Alternative
Beta catenin interacting protein 1, Inhibitor of beta-catenin and Tcf-4
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by BCA assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
11.3 kDa (101a) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Tago K., et al. (2000) Genes Dev. 14 (14) : 1741-9.; ; Daniels D.L., et al. (2002) Mol Cell 10:573-584;
Other References
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 100 mM NaCl
Scientific Category
Signal Transduction
NCBI Accession Number
NP_064633
Uniprot Accession Number
Q9NSA3
Species
Human
AA Sequence
MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q
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