Recombinant human S100Z protein

S100 calcium binding protein Z, also known as S100Z, is member of the S100 protein family. S100 proteins are small dimeric members of the EF-hand superfamily of Ca (2+) binding proteins thought to participate in mediating intracellular Ca (2+) signals by binding to and thereby regulating target proteins in a Ca (2+) -dependent manner. There are differences in the expression level of S100Z mRNA in various tissues. The highest levels were found in spleen and leukocytes. S100Z gene expression appears to be deregulated in some tumor tissues, compared to expression in their normal counterparts. Recombinant human S100Z, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.