Recombinant human NTAL protein
NTAL (non-T cell activation linker), as known as LAT2, is transmembrane adaptor protein (TRAP) associated with glycolipid-enriched membrane fractions (GEM or lipid rafts) . This protein is primarily expressed in spleen and hematopoietic cells, such as B cells, mast cells, NK cells, and monocytes, but not resting T cells. Defects in NTAL may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) . Recombinant human NTAL, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
26.2 kDa (238aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Naumann M., et al. (2010) Cell Signal. 22 (3) :395-403.; ; Gilfillan AM., et al. (2008) . Int J Biochem Cell Biol. 39 (5) : 868-873.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_115853.2
Uniprot Accession Number
Q9GZY6
Species
Human
AA Sequence
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