Recombinant human Apolipoprotein M/APOM protein
Apolipoproteins are protein components of plasma lipoproteins. APOM is a member of the lipocalin family of proteins. APOM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. APOM is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. It is important for the formation of prebeta-HDL and cholesterol efflux to HDL, and thereby inhibits formation of atherosclerotic lesions. The concentration of APOM in plasma strongly correlates with total cholesterol. Low concentrations of APOM in plasma are associated with diabetes. Recombinant human APOM protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Apolipoprotein M, G3a, HSPC336, NG20, Apolipoprotein M Apo M, ApoM, G3A, MGC22400, NG20 like protein, Protein G3a.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
20.9 kDa (187aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Jiang J., et al. (2008) Lipids Health Dis. 7:25. ; ; Duan J., et al. (2001) FEBS Lett. 499 (1-2) :127-32. ;
Other References
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Scientific Category
Adhesion & Movement
NCBI Accession Number
NP_061974
Uniprot Accession Number
O95445
Species
Human
AA Sequence
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