Recombinant human HSPB7 protein
HSPB7 is a member of HSPB (Heat shock protein beta) family. The HSPB family is one of the more diverse families within the group of HSP families. Some members have chaperone-like activities and/or play a role in cytoskeletal stabilization. Some members also show a dynamic, stress-induced translocation to SC35 splicing speckles. HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus. unlike HSPB1 and HSPB5, that chaperoned heat unfolded substrates and kept them folding competent, HSPB7 did not support refolding. Recombinant HSPB7 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
20.7 kDa (190aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
VOS MJ., et al. (2009) Biochim Biophys Acta. 1793 (8) :1343-53.; ; Matkovich SJ, et al. (2010) J Clin Invest. 120 (1) :280-9;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 200 mM NaCl, 2mM DTT, 50% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_055239
Uniprot Accession Number
Q9UBY9
Species
Human
AA Sequence
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