Recombinant human Profilin 4/PFN4 protein
Profilin-4, also known as PFN4, is a small actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton. It is found in all eukaryotic organisms in most cells. Also, this is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes. Recombinant human Profilin-4, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Profilin family member 4, Profilin-4, Profilin IV, Pfn4
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
16.4 kDa (149aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Witke W., et al. (2004) Trends Cell Biol. 14 (8) :461-9. ; ; Behnen M., et al. (2009) BMC Cell Biol. 10:34.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Scientific Category
Cytoskeleton
NCBI Accession Number
NP_955378
Uniprot Accession Number
Q8NHR9
Species
Human
AA Sequence
MSHLQSLLLD TLLGTKHVDS AALIKIQERS LCVASPGFNV TPSDVRTLVN GFAKNPLQAR REGLYFKGKD YRCVRADEYS LYAKNENTGV VVVKTHLYLL VATYTEGMYP SICVEATESL GDYLRKKGS
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