Recombinant human BAG1 protein

BCL2-associated athanogene, also known as BAG1, is a member of the Bcl-2 family of proteins that play varied stimulatory or inhibitory roles in the regulation of programmed cell death. This functions in conjunction with Bcl-2 to inhibit apoptosis. Also, BAG1 has been implicated in age related neurodegenerative diseases as Alzheimer's. It is localized to the cytosol, nucleus or both. Recombinant human BAG1 was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

BAG cochaperone 1, BCL2 associated athanogene, BCL2 associated athanogene 1, HAP, RAP46

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

25.9 kDa (230aa) confirmed by MALDI-TOF

Additionnal Information

BAG1, BCL2-associated athanogene 1, HAP, RAP46, BCL2-associated athanogene 1 Bag 1, BAG family molecular chaperone regulator 1, BCL 2 associated athanogene, BCL 2 Associated Athanogene 1, BCL 2 binding athanogene 1, BCL2 associated athanogene, BCL2 associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP1, Haptoglobin, RAP 46., ATGP0508-10 µg, ATGP0508-20 µg, ATGP0508-50 µg, ATGP0508-100 µg, ATGP0508-250 µg, ATGP0508-500 µg, ATGP0508-1 mg, ATGP0508-10, ATGP0508-20, ATGP0508-50, ATGP0508-100, ATGP0508-250, ATGP0508-500, ATGP0508-1

References & Citations

Wang HG., et al. (1996) Proc Natl Acad Sci u S A. 93 (14) :7063-8. ; ; Takayama S., et al. (1995) Cell. 80 (2) :279-84.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_001165886

Uniprot Accession Number

Q99933

Species

Human

AA Sequence

MNRSQEVTRD EESTRSEEVT REEMAAAGLT VTVTHSNEKH DLHVTSQQGS SEPVVQDLAQ VVEEVIGVPQ SFQKLIFKGK SLKEMETPLS ALGIQDGCRV MLIGKKNSPQ EEVELKKLKH LEKSVEKIAD QLEELNKELT GIQQGFLPKD LQAEALCKLD RRVKATIEQF MKILEEIDTL ILPENFKDSR LKRKGLVKKV QAFLAECDTV EQNICQETER LQSTNFALAE