Recombinant human RGS16 protein

RGS16, also known as regulator of G-protein signaling 16, belongs to 'regulator of G protein signaling' family and negatively regulates G protein coupled receptor signalling. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP bound form. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Recombinant RGS16 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Regulator of G-protein signaling 16, A28-RGS14, A28-RGS14P, RGS-R, Regulator of G-protein signaling 16 A28 RGS14, A28 RGS14P, HGNC:9997, Regulator of G protein signaling 16, Retinally abundant regulator of G protein signaling, RGS 16 RGS R, Rgs14, RGSR.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

24.9 kDa (222aa) confirmed by MALDI-TOF

Additionnal Information

RGS16, Regulator of G-protein signaling 16, A28-RGS14, A28-RGS14P, RGS-R, Regulator of G-protein signaling 16 A28 RGS14, A28 RGS14P, HGNC:9997, Regulator of G protein signaling 16, Retinally abundant regulator of G protein signaling, RGS 16 RGS R, Rgs14, RGSR., ATGP0499-10 µg, ATGP0499-20 µg, ATGP0499-50 µg, ATGP0499-100 µg, ATGP0499-250 µg, ATGP0499-500 µg, ATGP0499-1 mg, ATGP0499-10, ATGP0499-20, ATGP0499-50, ATGP0499-100, ATGP0499-250, ATGP0499-500, ATGP0499-1

References & Citations

Chen C., et al. (1997) J Biol Chem. 272 (13) :8679-85; ; Derrien A., et al. (2001) J Biol Chem. 276 (51) :48532-8;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl

Scientific Category

Signal Transduction

NCBI Accession Number

AAH06243

Uniprot Accession Number

O15492

Species

Human

AA Sequence

MCRTLAAFPT TCLERAKEFK TRLGIFLHKS ELGCDTGSTG KFEWGSKHSK ENRNFSEDVL GWRESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKIRSATKL ASRAHQIFEE FICSEAPKEV NIDHETRELT RMNLQTATAT CFDAAQGKTR TLMEKDSYPR FLKSPAYRDL AAQASAASAT LSSCSLDEPS HT