Recombinant human CTBP1 protein
C-terminal-binding protein 1 isoform 1, also known as CTBP1, is expressed from embryo to adult. This protein binds to the C-terminus of adenovirus E1A. It is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. Also, CTBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Recombinant human CTBP1 was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
C-terminal-binding protein 1 isoform 1, BARS, C-terminal-binding protein 1 isoform 1 C terminal binding protein 1, CTBP, CTBP1, MGC104684.
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
47.5 kDa (440aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Izutsu K., et al. (2001) Blood. 97 (9) :2815-22. ; ; Yu X., et al. (1998) J Biol Chem. 273:25388-25392. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 10% glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_001319.1
Uniprot Accession Number
Q13363
Species
Human
AA Sequence
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