Recombinant human CTBP1 protein

C-terminal-binding protein 1 isoform 1, also known as CTBP1, is expressed from embryo to adult. This protein binds to the C-terminus of adenovirus E1A. It is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. Also, CTBP1 associates in complexes with histone deacetylases (HDAC), the G9a histone methyltransferase, and LSD1 histone demethylase illustrating its role in transcriptional repression. Recombinant human CTBP1 was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

C-terminal-binding protein 1 isoform 1, BARS, C-terminal-binding protein 1 isoform 1 C terminal binding protein 1, CTBP, CTBP1, MGC104684.

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

47.5 kDa (440aa) confirmed by MALDI-TOF

Additionnal Information

CtBP1, C-terminal-binding protein 1 isoform 1, BARS, C-terminal-binding protein 1 isoform 1 C terminal binding protein 1, CTBP, CTBP1, MGC104684., ATGP0495-10 µg, ATGP0495-20 µg, ATGP0495-50 µg, ATGP0495-100 µg, ATGP0495-250 µg, ATGP0495-500 µg, ATGP0495-1 mg, ATGP0495-10, ATGP0495-20, ATGP0495-50, ATGP0495-100, ATGP0495-250, ATGP0495-500, ATGP0495-1

References & Citations

Izutsu K., et al. (2001) Blood. 97 (9) :2815-22. ; ; Yu X., et al. (1998) J Biol Chem. 273:25388-25392. ;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 10% glycerol

Scientific Category

Cell Cycle

NCBI Accession Number

NP_001319.1

Uniprot Accession Number

Q13363

Species

Human

AA Sequence

MGSSHLLNKG LPLGVRPPIM NGPLHPRPLV ALLDGRDCTV EMPILKDVAT VAFCDAQSTQ EIHEKVLNEA VGALMYHTIT LTREDLEKFK ALRIIVRIGS GFDNIDIKSA GDLGIAVCNV PAASVEETAD STLCHILNLY RRATWLHQAL REGTRVQSVE QIREVASGAA RIRGETLGII GLGRVGQAVA LRAKAFGFNV LFYDPYLSDG VERALGLQRV STLQDLLFHS DCVTLHCGLN EHNHHLINDF TVKQMRQGAF LVNTARGGLV DEKALAQALK EGRIRGAALD VHESEPFSFS QGPLKDAPNL ICTPHAAWYS EQASIEMREE AAREIRRAIT GRIPDSLKNC VNKDHLTAAT HWASMDPAVV HPELNGAAYR YPPGVVGVAP TGIPAAVEGI VPSAMSLSHG LPPVAHPPHA PSPGQTVKPE ADRDHASDQL