Recombinant human HSPB8 protein
Heat shock protein beta-8 (HSPB8), also known as HSP22, member of the small heat shock protein superfamily. HSPB8 is predominantly transcribed in skeletal muscle and heart. The chaperone-like activity is of great importance to the function of HSPB8 in various processes including proliferation, apoptosis and macroautophagy. Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) . Recombinant human HSPB8, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Heat shock protein beta-8, CRYAC, E2IG1, CMT2L, DHMN2, HMN2, HMN2A, Heat shock protein beta-8, heat shock 22kDa protein 8, H11, HSP22, HspB8
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
23.7 kDa (216aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Sun X., et al. (2004) J Biol Chem. 279 (4) :2394-402. ; ; Benndorf R., et al. (2001) J Biol Chem. 276:26753-61. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 20% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_055180.1
Uniprot Accession Number
Q9UJY1
Species
Human
AA Sequence
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