Recombinant human Galectin-9/LGALS9 protein

Galectin-9 (Gal-9) is a member of animal lectins that have an affinity to beta-galactosides and Forssman pentasaccharide. It is strongly overexpressed in Hodgkin's disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. Recombinant Galectin-9 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Specifications

The ED50 for this effect is equal or less than2.5 µg/mL. Measured by its ability to agglutinate human red blood cells.

Product Name Alternative

Galectin 9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, LGALS9A

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Bioactivity

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Bioactivity

The ED50 for this effect is equal or less than 2.5 µg/mL. Measured by its ability to agglutinate human red blood cells.

Molecular Weight

18.5 kDa (168aa) confirmed by MALDI-TOF

Additionnal Information

Galectin9, LGALS9, Gal-9, Tumor antigen HOM-HD-21, Ecalectin, galectin 9, HOM HD 21, HOMHD21, HuAT, Lectin galactoside binding soluble 9, LGAL S9, LGALS 9, LGALS9A, MGC117375, MGC125973, MGC125974, urate transporter/channel protein, galectin 9, ATGP0481-10 µg, ATGP0481-20 µg, ATGP0481-50 µg, ATGP0481-100 µg, ATGP0481-250 µg, ATGP0481-500 µg, ATGP0481-1 mg, ATGP0481-10, ATGP0481-20, ATGP0481-50, ATGP0481-100, ATGP0481-250, ATGP0481-500, ATGP0481-1

References & Citations

Tureci O, et al., (1997) J Biol Chem. 272 (10) :6416-22.; ; Zhu C, et al., (2005) Nat Immunol. 6 (12) :1245-52.

Other References

Fabregat FN et al., Structure of the Lipopolysaccharide from Paenalcaligenes hominis: A Chemical Perspective on Immune Recognition. (JACS Au. 2025) {https://doi.org/10.1021/jacsau.5c00441}

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1M NaCl

Scientific Category

Adhesion & Movement

NCBI Accession Number

NP_033665

Uniprot Accession Number

O00182

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MAFSGSQAPY LSPAVPFSGT IQGGLQDGLQ ITVNGTVLSS SGTRFAVNFQ TGFSGNDIAF HFNPRFEDGG YVVCNTRQNG SWGPEERKTH MPFQKGMPFD LCFLVQSSDF KVMVNGILFV QYFHRVPFHR VDTISVNGSV QLSYISFQ