Recombinant human HO-2/HMOX2 protein

HMOX2 is microsomal enzyme that cleave heme ring at the alpha methane bridge to produce the antioxidant biliverdin, inorganic iron and carbon monoxide. Biliverdin is subsequently converted to bilirubin by bilibverdin reductase. This protein appears to be constitutively expressed in mammalian tissues. HMOX2 is involved in the production of carbon monoxide (CO) in brain, where CO is thought to act as a neurotransmitter. Recombinant HMOX2 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Heme oxygenase 2, Heme oxygenase 2 Heme oxygenase (decycling) 2, Heme oxygenase (decyclizing) 2, HMOX 2, HMOX2 protein, HO 2, HO2

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

30.5 kDa (264aa) confirmed by MALDI-TOF

Additionnal Information

HO2, HMOX2, Heme oxygenase 2, Heme oxygenase 2 Heme oxygenase (decycling) 2, Heme oxygenase (decyclizing) 2, HMOX 2, HMOX2 protein, HO 2, HO2, ATGP0470-10 µg, ATGP0470-20 µg, ATGP0470-50 µg, ATGP0470-100 µg, ATGP0470-250 µg, ATGP0470-500 µg, ATGP0470-1 mg, ATGP0470-10, ATGP0470-20, ATGP0470-50, ATGP0470-100, ATGP0470-250, ATGP0470-500, ATGP0470-1

References & Citations

Baranano DE., et al. (2001) Proc Natl Acad Sci u S A. 98 (20) :10996-1002. ; ; Dore S., et al. (2002) Free Radic Biol Med. 32 (12) :1276-82.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Redox Proteins

NCBI Accession Number

NP_002125.3

Uniprot Accession Number

P30519

Species

Human

AA Sequence

MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE DGFPVHDGKG DMRK