Recombinant human Transthyretin/Prealbumin protein

Prealbumin, also known Transthyretin, is a tetrameric human plasma protein that is synthesized mainly in the liver. This protein transports the thyroid hormone thyroxine (T4) and retinol (Vitamin A) . It is the best indicator of protein-energy malnutrition because it has a circulating half life of 2 days and responds rapidly to changes in nutritional status. Also point-mutations of its gene are known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC) . Recombinant human Prealbumin was expressed in E. coli and purified by using conventional chromatography.

Product Specifications

Product Name Alternative

TTR, Transthyretin, TBPA, ATTR, PALB, Amyloid polyneuropathy, Amyloidosis I, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TTR protein.

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

13.8 kDa (128aa) confirmed by MALDI-TOF

Additionnal Information

Transthyretin, Prealbumin, TTR, Transthyretin, TBPA, ATTR, PALB, Amyloid polyneuropathy, Amyloidosis I, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TTR protein., ATGP0456-10 µg, ATGP0456-20 µg, ATGP0456-50 µg, ATGP0456-100 µg, ATGP0456-250 µg, ATGP0456-500 µg, ATGP0456-1 mg, ATGP0456-10, ATGP0456-20, ATGP0456-50, ATGP0456-100, ATGP0456-250, ATGP0456-500, ATGP0456-1

References & Citations

Ando Y., et al. (2009) Rinsho Byori. 57 (3) :228-35.; ; Shenkin A., et al. (2006) Clin Chem. 52 (12) :2177-9.;

Other References

Abdirama D, et al. Nuclear antigen-reactive CD4 + T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys. (Kidney Int. 2021) {https://pubmed.ncbi.nlm.nih.gov/32592813/}