Recombinant human Bcl-w protein

BCL2-like protein 2, also known as BCL2L2, is a member of the Bcl-2 family of proteins that regulates outer mitochondrial membrane permeability. BCL2L2 is an anti apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. It is required for normal sperm maturation. Recombinant human BCL2L2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

BCL2-like protein 2, Apoptosis regulator Bcl-W, BCLW, BCL2-like protein 2 Apoptosis regulator BCL W, BCL 2 Like 2, Bcl 2 like 2 protein, Bcl 2L2, bcl w, Bcl2 L2, BCL2 like 2, BCL2 like 2 protein, KIAA0271.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

20.9 kDa (192aa) confirmed by MALDI-TOF

Additionnal Information

Bcl-w, BCL2-like protein 2, Apoptosis regulator Bcl-W, BCLW, BCL2-like protein 2 Apoptosis regulator BCL W, BCL 2 Like 2, Bcl 2 like 2 protein, Bcl 2L2, bcl w, Bcl2 L2, BCL2 like 2, BCL2 like 2 protein, KIAA0271., ATGP0454-10 µg, ATGP0454-20 µg, ATGP0454-50 µg, ATGP0454-100 µg, ATGP0454-250 µg, ATGP0454-500 µg, ATGP0454-1 mg, ATGP0454-10, ATGP0454-20, ATGP0454-50, ATGP0454-100, ATGP0454-250, ATGP0454-500, ATGP0454-1

References & Citations

Zhu X., et al. (2004) J Neurochem. 89 (5) :1233-40. ; ; Kromer G., et al. (1997) Nature Med. 3:614. ;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 7.5) containing 100 mM NaCl, 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_004041

Uniprot Accession Number

Q92843

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RT