Recombinant human SURF1 protein

SuRF1, also known as surfeit 1, is a member of the SuRF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. This protein is localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. Defect in SuRF1 is a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. Recombinant SuRF1 protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Surfeit 1, Surfeit 1 SuRF 1, SuRF1, Surfeit locus protein 1, SURF1 cytochrome c oxidase assembly factor, SHY1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

24.3 kDa (215aa) confirmed by MALDI-TOF

Additionnal Information

SHY 1, SHY1, SuRF 1, SuRF1, SuRF-1, SURF1 cytochrome c oxidase assembly factor, Surfeit 1, Surfeit 1 SuRF 1, Surfeit locus protein 1, Surfeit locus protein1, Surfeit1, Surfeit-1, ATGP0451-10 µg, ATGP0451-20 µg, ATGP0451-50 µg, ATGP0451-100 µg, ATGP0451-250 µg, ATGP0451-500 µg, ATGP0451-1 mg, ATGP0451-010, ATGP0451-020, ATGP0451-050, ATGP0451-100, ATGP0451-250, ATGP0451-500, ATGP0451-01M

References & Citations

Pequignot MO., et al. (2001) Hum Mutat. 17 (5) :374-81. ; ; Zhu Z., et al. (1998) Nat Genet. 20 (4) :337-43. ;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.

Scientific Category

Redox Proteins

NCBI Accession Number

NP_003163

Uniprot Accession Number

Q15526

Species

Human

AA Sequence

MQVQRRKWKL NLIAELESRV LAEPVPLPAD PMELKNLEYR PVKVRGCFDH SKELYMMPRT MVDPVREARE GGLISSSTQS GAYVVTPFHC TDLGVTILVN RGFVPRKKVN PETRQKGQIE GEVDLIGMVR LTETRQPFVP ENNPERNHWH YRDLEAMARI TGAEPIFIDA NFQSTVPGGP IGGQTRVTLR NEHLQ

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