Recombinant human Frataxin protein
Frataxin, also known as FXN, is an iron binding protein which belongs to FRATAXIN family. It is an anti-apoptotic protein which prevents mitochondrial damage, reactive oxygen species production and act as either an iron chaperone or an iron storage protein. Frataxin is localized to the mitochondrion and regulating mitochondrial iron transport and respiration. Defects in this protein cause Friedreich ataxia. Recombinant Frataxin protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CyaY, FA, FARR, FRDA, X25, FXN, Friedreich ataxia protein.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
21.1 kDa (190aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Campuzano V., et al. (1996) Science. 271 (5254) :1423-7. ; ; Shan Y., et al. (2007) Hum Mol Genet. 16 (8) :929-41. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.5) containing 20% glycerol, 0.1M NaCl 1mM DTT
Scientific Category
Apoptosis
NCBI Accession Number
NP_000135.2
Uniprot Accession Number
Q16595
Species
Human
AA Sequence
Frequently Asked Questions
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