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Recombinant human CCL11/Eotaxin-1 protein

CCL11 is a small cytokine belonging to the CC chemokine family that is also known as eotaxin-1. CCL11 selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which CCL11 is a ligand include CCR2, CCR3 and CCR5. Recombinant CCL11 protein was expressed in E. coli and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Small inducible cytokine A11, SCYA11, Small inducible cytokine A11 CCL 11, Chemokine C C motif ligand 11, Chemokine CC Motif Ligand 11, Chemokine ligand 11, Eosinophil Chemotactic Protein, MGC22554, SCYA 11, Small inducible cytokine subfamily A (Cys Cys) member 11, Small inducible cytokine subfamily A member 11.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

10.6 kDa (95aa) confirmed by MALDI-TOF

Additionnal Information

CCL11, Eotaxin, Small inducible cytokine A11, SCYA11, Small inducible cytokine A11 CCL 11, Chemokine C C motif ligand 11, Chemokine CC Motif Ligand 11, Chemokine ligand 11, Eosinophil Chemotactic Protein, MGC22554, SCYA 11, Small inducible cytokine subfamily A (Cys Cys) member 11, Small inducible cytokine subfamily A member 11., ATGP0447-10 µg, ATGP0447-20 µg, ATGP0447-50 µg, ATGP0447-100 µg, ATGP0447-250 µg, ATGP0447-500 µg, ATGP0447-1 mg, ATGP0447-10, ATGP0447-20, ATGP0447-50, ATGP0447-100, ATGP0447-250, ATGP0447-500, ATGP0447-1

References & Citations

Imai T., et al. (1996) J Biol Chem. 271 (35) : 21514-21; ; Kakinuma T, ., et al. (2002) Cytokine. 20 (1) :1-6.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_002977

Uniprot Accession Number

P51671

Species

Human

AA Sequence

MGPASVPTTC CFNLANRKIP LQRLESYRRI TSGKCPQKAV IFKTKLAKDI CADPKKKWVQ DSMKYLDQKS PTPKP

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