Recombinant human BAALC protein
Brain and acute leukemia, cytoplasmic (BAALC) is localizes to both the membrane and the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed by hematopoetic and neural cells, BAALC interacts with CaMKIIalpha and is thought to play a role in synaptic function at postsynaptic lipid rafts. Overexpression of BAALC concomitant predict adverse clinical outcome and may define important risk factor in cytogenetically normal acute myeloid leukemia (AML) . Recombinant human BAALC, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Brain and acute leukemia cytoplasmic isoform 1, Brain and acute leukemia, cytoplasmic isoform 1 Brain and acute leukemia cytoplasmic, FLJ12015.
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
17.7 kDa (165aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Tanner SM., et al. (2001) Proc Natl Acad Sci u S A. 98 (24) :13901-6. ; ; Satoskar AA., et al. (2005) Gene Expr Patterns. 5 (4) :463-73. ;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 2mM EDTA
Scientific Category
Neuroscience
NCBI Accession Number
NP_079088
Uniprot Accession Number
Q8WXS3
Species
Human
AA Sequence
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