Recombinant human Glutaredoxin 2/GLRX2 protein
Glutaredoxin-2, as known as GRX2, multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. This protein is localized both in the mitochondria and nucleus. It has anti-apoptotic activity by preventing cardiolipin oxidation and cytochrome c release. GRX2 exhibited 36% identity with GRX1 and had a disulfide active center containing the Cys-Ser-Tyr-Cys motif. Recombinant human Glutaredoxin 2, fused to His-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
GLRX2, GRX2, CGI133, Glutaredoxin (thioltransferase) 2
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
17 kDa (154aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Elliott SJ., et al. (2009) Biochemistry. 948 (18) :3813-5.; ; Das DK., et al. (2008) J Mol Cell Cardiol. 44 (2) :252-60;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.1mM PMSF, 10% glycerol
Scientific Category
Redox Proteins
NCBI Accession Number
NP_932066
Uniprot Accession Number
Q9NS18
Species
Human
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