Recombinant human ATOX1 protein
Copper transport protein ATOX1, also known as HAH1, a metal transport protein that belongs to the ATX1 family. ATOX1 is involved in cellular antioxidant defense and can bind and deliver cytosolic copper to the copper ATPase proteins. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. Recombinant human ATOX1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
9.5 kDa (88aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Klomp LW., et al. (1997) J Biol Chem. 272 (14) :9221-6. ; ; Hamzal I., et al. (1999) Proc Natl Acad Sci uSA. 96 (23) :13363-8.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_004036
Uniprot Accession Number
O00244
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK TVSYLGLE
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