Recombinant human HSP70B/HSPA6 protein
HSP70B is a unique member of the human Hsp70 chaperone involved in cellular processes such as protein trafficking, folding, and prevention of aggregation. This protein is strictly stress-inducible, having little or no basal expression levels in most cells. HSP70B and Hsp72 are closely related and play cooperative roles in cell survival of proteotoxic stress. Recombinant human HSP70B, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Heat shock 70 kDa protein 6, HSPA6', Heat shock 70 kDa protein 6 Heat shock 70 kDa protein B'
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
73.2 kDa (663aa)
Additionnal Information
References & Citations
Noonan E., et al. (2008) . Exp Cell Res. 314 (13) :2468-76.; ; Hightower LE., et al. (2007) . Cell Stress Chaperones. 12 (4) :393-402.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 10% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_002146
Uniprot Accession Number
P17066
Species
Human
AA Sequence
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