Recombinant human Serpin A3/Alpha-1-antichymotrypsin protein
Alpha-1-antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. Recombinant alpha-1-antichymotrypsin protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
47.6 kDa (421aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Kamboh MI., et al. (2006) Neurobiol Aging. 27 (10) :1435-9. ; ; Tachikawa H., et al. (2001) J Hum Genet. 46 (1) :45-7.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Scientific Category
Neuroscience
NCBI Accession Number
NP_001076
Uniprot Accession Number
P01011
Species
Human
AA Sequence
Frequently Asked Questions
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