Recombinant human Serpin A3/Alpha-1-antichymotrypsin protein

Alpha-1-antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. Recombinant alpha-1-antichymotrypsin protein was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Serpin peptidase inhibitor clade A member 3, AACT, ACT, GIG24, GIG25, SERPINA3, Serpin peptidase inhibitor, clade A, member 3 Cell growth inhibiting gene 24/25 protein, Growth inhibiting protein 24, Antichymotrypsin, Growth inhibiting protein 25, MGC88254, Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3, Serine (or cysteine) proteinase inhibitor clade A member 3, Serine proteinase inhibitor clade A member 3, Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 95% by SDS-PAGE

Molecular Weight

47.6 kDa (421aa) confirmed by MALDI-TOF

Additionnal Information

Serpin A3, a1-antichymotrypsin, Serpin peptidase inhibitor clade A member 3, AACT, ACT, GIG24, GIG25, SERPINA3, Serpin peptidase inhibitor, clade A, member 3 Cell growth inhibiting gene 24/25 protein, Growth inhibiting protein 24, Antichymotrypsin, Growth inhibiting protein 25, MGC88254, Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3, Serine (or cysteine) proteinase inhibitor clade A member 3, Serine proteinase inhibitor clade A member 3, Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3., ATGP0420-10 µg, ATGP0420-20 µg, ATGP0420-50 µg, ATGP0420-100 µg, ATGP0420-250 µg, ATGP0420-500 µg, ATGP0420-1 mg, ATGP0420-10, ATGP0420-20, ATGP0420-50, ATGP0420-100, ATGP0420-250, ATGP0420-500, ATGP0420-1

References & Citations

Kamboh MI., et al. (2006) Neurobiol Aging. 27 (10) :1435-9. ; ; Tachikawa H., et al. (2001) J Hum Genet. 46 (1) :45-7.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT

Scientific Category

Neuroscience

NCBI Accession Number

NP_001076

Uniprot Accession Number

P01011

Species

Human

AA Sequence

HPNSPLDEE NLTQENQDRG THVDLGLASA NVDFAFSLYK QLVLKAPDKN VIFSPLSIST ALAFLSLGAH NTTLTEILKG LKFNLTETSE AEIHQSFQHL LRTLNQSSDE LQLSMGNAMF VKEQLSLLDR FTEDAKRLYG SEAFATDFQD SAAAKKLIND YVKNGTRGKI TDLIKDLDSQ TMMVLVNYIF FKAKWEMPFD PQDTHQSRFY LSKKKWVMVP MMSLHHLTIP YFRDEELSCT VVELKYTGNA SALFILPDQD KMEEVEAMLL PETLKRWRDS LEFREIGELY LPKFSISRDY NLNDILLQLG IEEAFTSKAD LSGITGARNL AVSQVVHKAV LDVFEEGTEA SAATAVKITL LSALVETRTI VRFNRPFLMI IVPTDTQNIF FMSKVTNPKQ A