Recombinant human p23/PTGES3 protein
Prostaglandin E synthase 3 (PTGES3), also known as P23 or TEBP (Telomerase binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. This protein is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Recombinant PTGES3 protein was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
Non-Tagged
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
18.6 kDa (160aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Hawkins GA., et al. (2009) J Allergy Clin Immunol. 123 (6) :1376-83.e7; ; Nuttinck F., et al. (2008) Reproduction. 135 (5) :593-603.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol
Scientific Category
Heat Shock Proteins
NCBI Accession Number
NP_006592
Uniprot Accession Number
Q15185
Species
Human
AA Sequence
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