Recombinant human GDF-15 protein

Growth differentiation factor 15 (GDF-15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. This protein is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 was expressed in E. coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Product Specifications

Product Name Alternative

Growth differentiation factor 15, GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, Growth differentiation factor 15 NSAID regulated protein 1, Placental TGF beta, GDF 15, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC 1, NAG 1, NAG1, NRG 1, NRG1, NSAID, NSAID (nonsteroidal anti inflammatory drug) activated protein 1, Placental bone morphogenetic protein, Placental bone morphogenic protein, Prostate differentiation factor, PTGF beta, PTGFB.

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

16.7 kDa (151aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)

Additionnal Information

GDF15, Growth differentiation factor 15, GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, Growth differentiation factor 15 NSAID regulated protein 1, Placental TGF beta, GDF 15, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC 1, NAG 1, NAG1, NRG 1, NRG1, NSAID, NSAID (nonsteroidal anti inflammatory drug) activated protein 1, Placental bone morphogenetic protein, Placental bone morphogenic protein, Prostate differentiation factor, PTGF beta, PTGFB., ATGP0410-10 µg, ATGP0410-20 µg, ATGP0410-50 µg, ATGP0410-100 µg, ATGP0410-250 µg, ATGP0410-500 µg, ATGP0410-1 mg, ATGP0410-10, ATGP0410-20, ATGP0410-50, ATGP0410-100, ATGP0410-250, ATGP0410-500, ATGP0410-1

References & Citations

Paralkar V.M, et al. (1998) J Biol Chem. 273:13760-13767.; ; Hsiao E, Koniaris L., et al. (2000) Mol Cell Biol 20 (10) :3742-51. ;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 10 mM Sodium Citrate buffer (pH 3.5) containing 10% glycerol

Scientific Category

Growth factors

NCBI Accession Number

NP_004855

Uniprot Accession Number

Q99988

Species

Human

AA Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I